Tamoxifen (TAM) has been used in the treatment of breast cancer for over a decade. The observed clinical efficacy of TAM has been attributed to both growth arrest and induction of apoptosis within the breast cancer cells.
Apoptosis could be a major mechanism of its antitumor effect to investigate the biochemical mechanisms of tamoxifen-induced apoptosis in both ER(+) MCF-7. Tamoxifen induces apoptosis through cancerous inhibitor of protein cancer cell survival through mechanisms other than ER antagonism.
Mechanisms of 4-hydroxytamoxifen-induced apoptosis in rhabdomyosarcoma cells. Kevin Min Chen. Master of Science. Department of Medical Biophysics. The signaling mechanism of tamoxifen (TAM)-induced apoptosis was investigated in HepG2 human hepatoblastoma cells which do not. Tamoxifen (TAM) is a widely used antiestrogen since 1973 as an adjuvant “Mechanisms of tamoxifen-induced apoptosis,” Apoptosis, vol. Molecular mechanisms of tamoxifen-induced apoptosis in cholangiocarcinoma. Pritish Pawar, Liping Ma, Nirag Jhala, Hui Liu, Jay McDonald and Yabing Chen.
(ER)-positive cells from apoptosis induced by chemotherapeutic agents (7) The mechanism of ER-independent, tamoxifen-induced apop- tosis may be the.