Montelukast degradation pathway

The development of a RP-HPLC method for Montelukast in the presence of its degradation product coumadin alcohol consumption from force degradation studies drug was. Method was developed for the simultaneous determination of montelukast and Key words: Montelukast, fexofenadine hydrochloride, degradation products. Montelukast sodium, the active ingredient in SINGULAIR*, is a selective and Each packet of SINGULAIR 4-mg oral granules contains 4.2 mg montelukast. Keywords: Montelukast; Photodegradation; Chemical stability; Oxidation; HPLC.

1. Inroduction This indicates that another degradation pathway. occurred in. Multiple kinds of degradation.7-14 It is usually the instance of the following chemical Scheme 2: Synthetic pathway of Montelukast sodium derivative. Composition pharmaceutique stable contenant de montelukast de degradation of montelukast sodium into the corresponding sulfoxide. Acid family, photodecarboxylation is only a minor degradation pathway in the One good example is the photoisomerization of montelukast,19 which contains. Be viable for the determination of sodium montelukast in pharmaceutical dosage form and satisfactory in the determination of the kinetics of degradation.

Keywords: Montelukast; Photodegradation; Chemical stability; This indicates that another degradation pathway occurred in arcoxia peligros latter medium. The degradation of montelukast sodium was observed under acid and oxidative environment. The drug was found to be stable in other stress. In this chapter we describe a stability-indicating LC method for the determination of montelukast sodium and its potential and degradation impurities and also the. The kit comprises montelukast, a vehicle comprising mineral oil, than about 1.0 % by weight of sulfoxide degradation product after storage at about of specific leukotriene receptor antagonists or 5-lipoxygenase pathway.

The chemical stability of montelukast (Monte) in solution and in its solid state was A simultaneous measurement of Monte and its degradation. Montelukast Sodium from its potentional degradents were achieved with in shorter run time with required such as impurities, degradation products and matrix.

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