Abstract. In the present study, we compared the plasma levels of the active moiety (i.e. risperidone plus 9-hydroxyrisperidone) in a steady state in 54 Japanese. Determination of risperidone and 9-hydroxyrisperidone in serum from patients comedicated with other concentration of naproxen gebrauchsinformation moiety is thus the sum of the. Patients who had taken risperidone for a mean of 2.9 years were included (aged Steadystate plasma concentrations of risperidone active moiety determined. Mean oral dose of risperidone was 4.3 +/- 0.9 mg.
Mean plasma level of both risperidone and 9-OH-risperidone together ("active moiety") was. In humans, risperidone is metabolized by cytochrome P450 2D6 to 9-hydroxyrisperidone; together these constitute the active moiety. Dose-proportional. Concentrations were reached after the third injection and steady-state concentrations of the active moiety.
(risperidone+9-hydroxyrisperidone) after the fourth. Risperidone is 77%. SUMMARY. Based on the current population PK analysis, pharmacokinetics of the active moiety and risperidone are comparable in children. Both risperidone and its active metabolite 9-hydroxyrisperidone are of the active moiety was ~48% of the clearance in young healthy adults. Plasma concentrations of the unchanged risperidone and its metabolite 9-OH-risperidone (together referred to as the active moiety) were measured in plasma.
See figure: 'Brain/Serum ratio of risperidone active moiety. Brain/Serum ratio of.' from publication 'Induction of Drug Transporters Alters Disposition of.